上海交通大学环境科学与工程学院 上海交通大学环境科学与工程学院

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张琨(Zhang Kun)
张琨(Zhang Kun) 长聘教轨副教授

电子邮件:kunzhang@sjtu.edu.cn
办公室电话:18818207712
办公地点:印刷厂楼315

研究方向

研究领域:

环境分析监测,环境污染物行为,环境健康

现阶段主要研究方向:

环境中新型污染物的分析监测及其来源和环境行为解析

环境中未知污染污染物的非靶标筛查和鉴定

环境污染物质对健康,特别是对神经发育的影响

个人简历

2003-2007 北京大学,城市与环境学院 环境科学, 理学学士
2007-2012 北京大学,城市与环境学院 环境地理学, 理学博士
2012-2015 加拿大阿尔伯塔大学, 实验医学与病理学系, 博士后
2015-2016 瑞士西北应用科技大学,生态环境研究所, 博士后
2017-2018 美国哈佛医学院/布莱根妇女医院,高级研究助理

代表性论著

1. Zhang, K.; Zhao, Y. B.*Reduced Zebrafish Transcriptome Atlas toward Understanding the Environmental Neurotoxicants. Environ. Sci. Technol.2018, 52 (12), 7120-7130.

2. Zhang, K.; Fent, K. Determination of two progestin metabolites (17α-hydroxypregnanolone and pregnanediol) and different classes of steroids (androgens, estrogens, corticosteroids, progestins) in rivers and wastewaters by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Sci. Total Environ.2018, 610, 1164-1172.

3. Zhang, K.; Zhao, Y.; Fent, K. Occurrence and ecotoxicological effects of free, conjugated and halogenated steroids of 17α-hydroxypregnanolone and pregnanediol in Swiss wastewater and surface water. Environ. Sci. Technol., 2017, 51 (11), 6498–6506.

4. Zhang, K.; Wiseman, S. B.; Giesy, J. P.; Martin, J. W. Bioconcentration of Dissolved Organic Compounds from Oil Sands Process-Affected Water by Medaka (Oryzias latipes): Importance of Partitioning to Phospholipids. Environ. Sci. Technol. 2016, 50 (12), 6574–6582.

5. Zhang, K.; Pereira, A. S.; Martin, J. W. Estimates of Octanol–Water Partitioning for Thousands of Dissolved Organic Species in Oil Sands Process-Affected Water. Environ. Sci. Technol. 2015, 49 (14), 8907-8913.

6. Zhang, K.; Wan, Y.; Jones, P. D.; Wiseman, S.; Giesy, J. P.; Hu, J. Y. Occurrences and Fates of Hydroxylated Polybrominated Diphenyl Ethers in Marine Sediments in Relation to Trophodynamics. Environ. Sci. Technol. 2012, 46 (4), 2148−2155

7. Zhang, K.; Wan, Y.; Giesy, J. P.; Lam, MHW; Wiseman, S.; Jones, P. D.; Hu, J. Y. Tissue Concentrations of Polybrominated Compounds in Chinese Sturgeon (Acipenser sinensis): Origin, Hepatic Sequestration, and Maternal Transfer. Environ. Sci. Technol. 2010, 44 (15), 5781-5786.

8. Zhang, K.; Wan, Y.; An, L. H.; Hu, J. Y. Trophodynamics of Polybrominated Diphenyl Ethers and Methoxylated Polybrominated Diphenyl Ethers in a Marine Food Web. Environ. Toxicol. Chem. 2010, 29 (12), 2792-2799.

9.         Siegenthaler, P. F.; Zhao, Y.; Zhang, K.; Fent, K. Reproductive and transcriptional effects of the antiandrogenic progestin chlormadinone acetate in zebrafish (Danio rerio). Environ. Pollut. 2017, 223, 346-356.

10.     Morandi, G. D.; Zhang, K.; Wiseman, S. B.; Pereira, A. d. S.; Martin, J. W.; Giesy, J. P. Effect of Lipid Partitioning on Predictions of Acute Toxicity of Oil Sands Process Affected Water to Embryos of Fathead Minnow (Pimephales promelas). Environ. Sci. Technol. 2016, 50 (16), 8858-8866.

11.     Zhao, Y.; Zhang, K.; Fent, K. Corticosteroid Fludrocortisone Acetate Targets Multiple End Points in Zebrafish (Danio rerio) at Low Concentrations. Environ. Sci. Technol. 2016, 50 (18), 10245-10254.

12.     Rossier, N. M.; Chew, G.; Zhang, K.; Riva, F.; Fent, K. Activity of binary mixtures of drospirenone with progesterone and 17α-ethinylestradiol in vitro and in vivo. Aquat. Toxicol. 2016, 174, 109-122.

13.     Zhao, Y. ; Zhang, K.; Giesy, J. P.; Hu, J. Families of nuclear receptors in vertebrate models: characteristic and comparative toxicological perspective. Scientific reports 2015, 5, 8554.

14.     Peng, H.; Wan, Y.; Zhang, K.; Sun, J. X.;Hu, J. Y. Trophic Transfer of Dechloranes in the Marine Food Web of Liaodong Bay, North China. Environ. Sci. Technol. 2014, 48 (10), 5458−5466

15.     Wan, Y.; Zhang, K.; Dong, Z. M.; Hu, J. Y. ; Distribution is a Major Factor Affecting Bioaccumulation of Decabrominated Diphenyl Ether: Chinese Sturgeon (Acipenser sinensis) as an Example. Environ. Sci. Technol. 2013, 47 (5), 2279−2286

16.     Peng, H.; Zhang, K.; Wan, Y.; Hu, J. Y. Tissue Distribution, Maternal Transfer, and Age-Related Accumulation of Dechloranes in Chinese Sturgeon. Environ. Sci. Technol. 2012, 46 (18), 9907−9913

17.      Wan, Y.; Jones, P. D.; Wiseman, S.; Chang, H.; Chorney, D.; Kannan, K.; Zhang, K.; Hu, J. Y.; Khim, J. S.; Tanabe, S.; Lam, MHW; Giesy, J. P. Contribution of Synthetic and Naturally Occurring Organobromine Compounds to Bromine Mass in Marine Organisms. Environ. Sci. Technol. 2010, 44 (16), 6068-6073.

18.      Wan, Y.; Hu, J. Y. ; Zhang, K.; An, L. H. Trophodynamics Of Polybrominated Diphenyl Ethers in the Marine Food Web of Bohai Bay, North China. Environ. Sci. Technol. 2008, 42 (4), 1078-1083.

研究成果
近年来主要致力于环境污染物质的环境行为研究。利用气相/超高效液相质谱联用检测技术结合体外微粒体暴露,微生物降解,PBPK模型模拟,野外样品采集分析对环境污染物质的来源降解和在不同结构的食物网中的生物富集差异及受污染物药代行为学的影响等一系列环境行为开展了独创性的研究工作。同时,利用超高分辨质谱非靶向检测技术结合生物模拟和鱼体暴露等方法开发了对环境中复合有机污染物的毒性和生物富集性评估方法平台,并将其成功应用于油砂废水中获得污染物优先控制名单。以上研究成果共发表SCI 论文18 篇,其中13篇发表在环境科学权威杂志Environ. Sci. Technol.(IF 6.2)上。一作文章8 篇,6篇发表在Environ. Sci. Technol.上。
荣获奖项

2010 陶氏可持续发展创新学生挑战赛学生奖

2009 林超地理学奖学金

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