赵砚彬(Zhao Yanbin) - 上海交通大学环境科学与工程学院

基本介绍

上海交通大学教授、博士生导师，环境科学与工程学院副院长，国家自然科学基金优秀青年科学基金、上海市“浦江人才”计划项目获得者。国际权威SCI期刊Eco-Environment & Health青年编委，ACS ES&T Water杂志编委会委员。中国环境诱变剂学会出生缺陷防治专业委员会委员。
致力于污染物环境健康效应研究。运用环境分析化学、分子生物学、生物信息学与人工智能技术，围绕新污染物环境健康风险识别和毒性效应与机制开展系统深入研究工作。主持国家自然科学基金优秀青年基金、面上基金、国家重点研发计划子课题、上海市浦江人才计划项目等研究项目。在环境新污染物环境健康效应研究方面取得了系列创新成果，在Environ. Sci. Technol.、Proc. Natl. Acad. Sci. U.S.A.等环境领域及重要国际综合类SCI期刊上发表论文近70篇，获授权国家发明专利2项，参与编撰中英文专著2部。
课题组聚焦环境分析化学、环境健康与人工智能交叉研究，围绕新污染物非靶向筛查、环境暴露与健康风险评估、高通量生物测试及环境健康大数据智能解析等方向开展具体研究工作。欢迎具有环境科学、化学、生物学、人工智能及数据科学等相关背景的同学参与本科生科研、研究生培养及博士后研究工作。
文章发表列表详见Google Scholar: https://scholar.google.com/citations?hl=zh-CN&user=EfM4al4AAAAJ&view_op=list_works&sortby=pubdate

工作经历

2024-12-上海交通大学环境科学与工程学院,教授
2024-09-上海交通大学环境科学与工程学院,副院长
2018-09-2024-12：上海交通大学环境科学与工程学院,长聘教轨副教授/长聘副教授
2016-10-2018-08：美国哈佛大学医学院布莱根妇女医院,博士后
2014-03-2016-07：瑞士西北应用科技大学生态环境研究所,博士后
2007-09-2013-07：北京大学城市与环境学院环境科学,理学博士
2003-09-2007-07：西北农林科技大学生命科学学院生物技术,理学学士

研究方向

新污染物非靶向筛查与智能识别方法 Non-Targeted Screening and Intelligent Identification of Emerging Contaminants
新污染物环境行为与暴露特征评估 Environmental Fate and Exposure Assessment of Emerging Contaminants
高通量生物测试与毒性效应机制研究 High-Throughput Bioassays and Toxicity Mechanisms
人工智能驱动的环境健康大数据分析 AI-Driven Environmental Health Data Analytics

科研项目

国家自然科学基金-面上项目：典型氟苯液晶TFPPC致斑马鱼胚胎类“海豹肢畸形”发育毒性机制研究，主持
国家自然科学基金-优秀青年科学基金项目：环境激素的生殖和发育毒性，主持
国家自然科学基金-面上项目：有机磷酸酯心血管毒性效应识别与毒性作用机制研究，主持
国家重点研发计划项目：典型塑料添加剂危害性筛查及预测关键技术，骨干参与
国家重点研发计划项目：儿童常见发育行为性疾病的早期诊断与干预及预警体系建立，骨干参与
上海市科学技术委员会-浦江人才计划项目：典型环境皮质激素倍他米松和氟氢可的松心血管毒性效应及作用机理研究，主持
上海交通大学医工交叉项目：逆转白色念珠菌对佛康唑耐药的新型抗真菌药物筛选及机制研究，交大-负责人

论文信息

Jing, K.; Wang, R.; Chen, S.; Zuo, S.; Zhang, K.; Dai, j.; Qin, X.*; Zhao, Y. B.* Circadian Receptor-Guided Screening for Environmental Circadian Disruptor Discovery. Environ. Sci. Technol. Lett. 2026, 13 (5), 677-683.
Zhao, N.; Deng, X.; Dong, R.*; Zhao, Y. B.* Bridging Toxicological Silos with Organoids: A Systems Approach to Human-Relevant Risk Assessment. Environ. Sci. Technol. 2026, 60 (13), 9831-9842.
Zeng, M.; Huang, J.; Chen, M.; Wu, J.; Zhao, Y. B.*; Tu, W.* Transcriptomics-Guided Outcome Prediction (T-GOP) for Ecotoxicity Assessment: A Proof-of-Concept Study of PFOS Alternative OBS Disrupting Zebrafish Neurotransmitter Homeostasis and Cognition. Environ. Sci. Technol. 2026, 60 (11), 8379-8392.
Wang, P.; Li, Y.*; Zhang, Z.; Chen, J.; Zhang, K.; Dai, J.; Fent, K.; Zhao, Y. B.* Suspect List-Guided High-Throughput Screening (SLIG-HTS) Identifies Environmental Substances Associated with Advanced Embryonic Developmental Timing. Environ. Sci. Technol. 2026, 60 (7), 5350-5362.
Zheng, X.; Shi, H.; Li, B.; Li, J.; Liu, Y.; Liang, J.; Chen, L.; Fent, K.; Zhang, K.; Wang, H.; Dai, J.; Zhao, Y. B.* Identification of toxic substances considering circadian disruption: an integrated approach combining reduced transcriptomic analysis, behavioral monitoring, and time-course gene expression profiling. Environ. Int. 2026, 208, 110111.
Wang, Y.; Shi, H.; Zheng, X.; Wang, C.; Meng, H.; Shen, J.; Zhang, K.; Zu, Y.; Zhao, Y. B.* Systematic Toxicity Screening and Developmental Hazard Assessment of Electronic Display-Related Organic Materials Environ. Sci. Technol. Lett. 2026, 13 (2), 193-200.
An, R.; Wang, J.; Cao, L.; Yue, X.; Zheng, S.; Zhao, Y. B.*; Dai, J.; Zhang, K.* Environmental Risks of Thermal Insulation Manufacturing under Global Decarbonization: A Case Study of Organophosphate Esters Using Targeted and Nontargeted Analyses. Environ. Sci. Technol. 2025,59 (48), 26157-26170.
Zuo, S.; Zhang, K.; Dai, J.; Fent, K.; Huang, A. Y.; Zhao, Y. B.* Genetic Polymorphisms in Nuclear Receptors Drive Variations in Responses to Environmental Exposures. Environ. Sci. Technol. 2025, 59 (37), 19733-19744.
Wang C, Gui W, Zhang K,* Cao L, An R, Zhou J, Li M, Chen X, Wang H, Dai J, Zhao Y. B.* Typical Thermochromic Dye Crystal Violet Lactone Acts as an Endocrine Disruptor: Nontargeted Screening, Prioritization, and In Vivo Experimental Verification. Environ. Sci. Technol. 2025, 59(26), 13227-13239.
Li H, Dong K, Zhao M, Li R, Shi C, Wang C, Wei Y, Li J, Chen L, Zhao Y. B.,* Li Y.* 6:2 Chlorinated Polyfluoroalkyl Ether Sulfonate (F-53B) Induces Aging and Parkinson's Disease-like Disorders in C. elegans at Low Concentrations. Environ. Sci. Technol. 2025, 59(28), 14249-14257.
Chen J, Li B, Zuo S, Zhang K, Dai J, Chen L.,* Zhao Y. B.* Pattern Recognition-Driven Detection of Circadian-Disruptive Compounds from Gene Expressions: High-Throughput Screening and Experimental Verification. Environ. Sci. Technol. 2025, 59 (12), 5960-5972.
Zhang Z, Shi H, Zhang K,* An R, Wang C, Wang P, Chan SA, Song Y, Dai J, Zhao Y. B.* Transcriptome-Guided Characterization of the Environmental Toxicity of Metformin: Disruption of Energy Homeostasis and Inhibition of Embryonic Development of Zebrafish at Environmentally Relevant Concentrations. Environ. Sci. Technol. 2024, 58 (40), 17580-17591.
Shi H, Zhao Y. B.* Integration of Advanced Large Language Models into the Construction of Adverse Outcome Pathways: Opportunities and Challenges. Environ. Sci. Technol. 2024, 58 (35), 15355-15358.
Chen J, Wang C, Tu W, Zhang K, Fent K, Dai J, Hecker M, Giesy JP, Zhao Y. B.* AOP-Anchored Transcriptome Analysis Catalogue Accelerates the Discovery of Environmental Toxicants in Zebrafish. Environ. Sci. Technol. 2024, 58 (30), 13217-13225.
Zheng, S.; Wang, J.; Luo, K.; Gu, X.; Yuan, G.; Wei, M.; Yao, Y.; Zhao, Y. B.; Dai, J. Y.; Zhang K.* Comprehensive Characterization of Organic Light-Emitting Materials in Breast Milk by Target and Suspect Screening. Environ. Sci. Technol. 2024, 58 (11), 5103-5116.
Wang, C.; Li, M.; Gui, W.; Shi, H.; Wang, P.; Chen, J.; Fent, K.; Zhang, K.; Dai, J.; Li, X.; Zhao, Y. B.* Prednisolone Accelerates Embryonic Development of Zebrafish via Glucocorticoid Receptor Signaling at Low Concentrations. Environ. Sci. Technol. 2023 , 57 (42), 15794-15805.
Shi, H.; Li, M.; Meng, H.; Zheng, X.; Zhang, K.; Fent, K.; Dai, J.; Zhao, Y. B.* Reduced Transcriptome Analysis of Zebrafish Embryos Prioritizes Environmental Compounds with Adverse Cardiovascular Activities. Environ. Sci. Technol. 2023, 57 (12), 4959-4970.
Zuo, S. Q.; Meng, H. Y.; Liang, J. H.; Zhen, H. J.; Zhu, Y.; Zhao, Y. B.; Zhang, K.*; Dai, J. Residues of Cardiovascular and Lipid-Lowering Drugs Pose a Risk to the Aquatic Ecosystem despite a High Wastewater Treatment Ratio in the Megacity Shanghai, China. Environ. Sci. Technol. 2022, 56 (4), 2312-2322.
Wang, J.; Nan, J.; Li, M.; Yuan, G.; Zhao, Y. B.; Dai, J.; Zhang, K.* First evidence of contamination in aquatic organisms with organic light-emitting materials. Environ. Sci. Technol. Lett. 2022, 9, 739-746.
Shen, J.; Shi, H. C.; Zhao, Y. B.; Fent, K.; Zhang, K.* Large-Scale Transcriptional Profiling of Molecular Perturbations Reveals Cell Line Specific Responses and Implications for Environmental Screening. Environ. Sci. Technol. 2021, 55 (22), 15266-15275.
Zhang, K.; Liang, J.; Brun, N. R.; Zhao, Y. B.*; Werdich, A. A. Rapid zebrafish behavioral profiling assay accelerates the identification of environmental neurodevelopmental toxicants. Environ. Sci. Technol. 2021, 55 (3), 1919-1929.
Zhao, Y. B.; Liang, J.; Meng, H.; Yin, Y.; Zhen, H.; Zheng, X.; Shi, H.; Wu, X.; Zu, Y.; Wang, B.; Fan, L.; Zhang, K.* Rare Earth Elements Lanthanum and Praseodymium Adversely Affect Neural and Cardiovascular Development in Zebrafish (Danio rerio). Environ. Sci. Technol. 2021, 55 (2), 1155-1166.
Zheng, X. H.; Zhang, K.; Zhao, Y. B.*; Fent, K.* Environmental Chemicals Affect Circadian Rhythms: an Underexplored Effect Influencing Health and Fitness in Animals and Humans. Environ. Int. 2021, 106159.
Liang, J. H.; Meng, H. Y.; Zhou, J.; Yin, Y.; Zhen, H. J.; Zhao, Y. B.*; Zhang, K.* Simultaneous Occurrence of Psychotropic Pharmaceuticals in Surface Water of the Megacity Shanghai and Implication for Their Ecotoxicological Risks. ACS ES&T Water 2021, 1 (4), 825-836.

获奖信息

2024年上海交通大学年度教学成果奖一等奖（7/8）
2024年环境科学与工程学院最受欢迎教师奖
2023年上海交通大学青年教师教学竞赛三等奖
2023年上海交通大学优秀班主任
2022年环境科学与工程学院青年教师教学竞赛二等奖
2021年环境科学与工程学院年度考核优秀个人
2021年国家优秀青年科学基金获得者
2019年上海交通大学青年教师教学竞赛三等奖
2019年环境科学与工程学院青年教师教学竞赛二等奖
2019年上海市浦江人才计划项目获得者
2016年瑞士FHNW生态环境研究所年度杰出论文奖