研究方向

1.      新型环境污染物的危害识别和高通量筛查

2.      新型环境污染物毒性效应的分子机制研究

3.      环境污染物与生物大分子的相互作用及其生物毒性效应

个人简历

    2018年于中国科学院动物研究所获得理学博士学位；2018-2020年，于中国科学院动物研究所开展博士后研究，研究工作包括：新型多氟及全氟烷基化合物对小鼠的肝脏毒性及机制、多氟及全氟化合物与关键生物大分子间的相互作用。

    2020年至今，上海交通大学环境科学与工程学院，长聘教轨助理教授

代表性论著

1.       Sheng N, Wang J, Guo Y, Wang J and Dai J. Interactions of perfluorooctanesulfonate (PFOS) and 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA) with human serum albumin (HSA): A comparative study [J]. Chemical Research in Toxicology. 2020, 33(6): 1478-1486.

2.       Sheng N, Pan Y, Guo Y, Sun Y and Dai J. Hepatotoxic effects of hexafluoropropylene oxide trimer acid (HFPO-TA), a novel perfluorooctanoic acid (PFOA) alternative, on mice at low dosage exposure[J]. Environmental Science & Technology. 2018, 52(14):8005-8015.

3.       Sheng N, Cui R, Wang J, Guo Y, Wang J and Dai J. Cytotoxicity of novel fluorinated alternatives to long-chain perfluoroalkyl substances to human liver cell line and their binding capacity to human liver fatty acid binding protein[J]. Archives of Toxicology. 2018, 92(1):359-369.（高被引论文）

4.       Sheng N, Zhou X, Zheng F, Pan Y, Guo X, Guo Y, Sun Y and Dai J. Comparative hepatotoxicity of 6:2 fluorotelomer carboxylic acid and 6:2 fluorotelomer sulfonic acid, two fluorinated alternatives to long-chain perfluoroalkyl acids, on adult male mice[J]. Archives of Toxicology. 2017, 91(8):2909-2919.

5.       Sheng N, Li J, Liu H, Zhang A and Dai J. Interaction of perfluoroalkyl acids with human liver fatty acid-binding protein[J]. Archives of Toxicology. 2016, 90(1):217-27.

6.       Zhang W¹, Sheng N¹, Wang M, Zhang H and Dai J. Zebrafish reproductive toxicity induced by chronic perfluorononanoate exposure[J]. Aquatic Toxicology. 2016, 175:269-76.

研究成果

1. 基于分子与蛋白相互作用的新型全氟聚醚羧酸在小鼠体内分布机制研究 （青年科学基金项目： 21906160）