Search

Close
Jiahua CUI
Assistant Researcher
E-mail：cpucjh@sjtu.edu.cn
Telephone：86-21-34204775
Address：Room 502, Block 7, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai

Research Interests

  1. Environmental Toxicology and Chemistry
  2. Chemoprevention

Biography

2019-Present     Assistant Research Fellow, School of Environmental Science and Engineering, Shanghai Jiao Tong University

2016-2018    Postdoctoral Fellow in Biology supported by “Hong Kong Scholar Program”, Department of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University

2014-2015    Postdoctoral Fellow in Biology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University

2010-2014  M.D. in Medicinal Chemistry, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China

Selected Publications

  1. Gege Sun, Iris L. Wong, Jiahua Cui, Zhen Liu, Bill T. Chan, Larry M. Chow. Investigate the mechanism of actions of flavonoid dimers in reversing doxorubicin resistance in breast cancer stem cells. Cancer Res., 2020, 80 (16 Suppl), Abstract nr 3795.

  2. Jinyun Dong, Guang Huang, Qing Cui, Qingqing Meng, Shaoshun Li* and Jiahua Cui*. Discovery of Heterocycle-Containing α-Naphthoflavone Derivatives as Water-Soluble, Highly Potent and Selective Cyp1b1 Inhibitors. Eur. J. Med. Chem., 2020, 112895, DOI: 10.1016/j.ejmech.2020.112895.

  3. Jiahua Cui* and Jinping Jia*. Natural COX-2 inhibitors as promising anti-inflammatory agents: an update. Curr. Med. Chem., 2020, DOI: 10.2174/0929867327999200917150939.

  4. Jiahua Cui*, Shaoshun Li and Jinping Jia*. A regioselective synthesis of 7-methyl juglone and its derivatives. Nat. Prod. Res., 2020, DOI: 10.1080/14786419.2020.1761356.

  5. Jiahua Cui#, Xu Zhang#, Guang Huang#, Qijiang Zhang, Jinyun Dong, Gege Sun, Qingqing Meng* and Shaoshun Li*. DMAKO-20 as a new multi-target anticancer prodrug activated by the tumor specific CYP1B1 enzyme. Mol. Pharmaceutics, 2019, 16 (1), 409-421.
  6. Jiahua Cui*, Xiaoyang Liu and Larry M. C. Chow. Flavonoids as P-gp inhibitors: a systematic review of SARs. Curr. Med. Chem., 2019, 26 (25), 4799-4831.
  7. Jiahua Cui#, Qingqing Meng#, Xu Zhang, Qing Cui, Wen Zhou and Shaoshun Li*. Design and synthesis of new α-naphthoflavones as cytochrome P450 (CYP) 1B1 inhibitors to overcome docetaxel-resistance associated with CYP1B1 overexpression. J. Med. Chem., 2015, 58(8), 3534-3547.
  8. Jiahua Cui, Qing Cui, Qijing Zhang, Shaoshun Li. An efficient multigram synthesis of juglone methyl ether. J. Chem. Res., 2015, 39(9), 553-554.
  9. Jiahua Cui and Shaoshun Li. Inhibitors and prodrugs targeting CYP1: a novel approach in cancer prevention and therapy. Curr. Med. Chem., 2014, 21(5), 519-552.
  10. Jiahua Cui and Shaoshun Li. An efficient synthesis of 5,6-dimethoxy 1- and 2-naphthols via Teuber reaction. J. Chin. Chem. Soc., 2013, 60(9), 1163-1168.
  11. Jiahua Cui and Shaoshun Li. Structure, chemistry and pharmacology of naphthoflavones. Mini-Rev. Med. Chem., 2013, 13(9), 1357-1368.
  12. Jiahua Cui, Dagula Hu, Xu Zhang, Zheng Jing, Jing Ding, Rubing Wang and Shaoshun Li. Design and synthesis of new 7,8-dimethoxy-α-naphthoflavones as CYP1A1 inhibitors. Chin. Chem. Lett., 2013, 24(3), 215-218.
  13. Jiahua Cui and Shaoshun Li. A convenient and efficient synthesis of 2,6-dihydroxynaphthalene. J. Chem. Res., 2012, 36(11), 675-677.
  14. Jiahua Cui, Wen Zhou and Shaoshun Li. A convenient and efficient synthesis of 2-acetyl-5,8-dimethoxy-1,4-naphthoquinone. J. Chem. Res., 2012, 36(5), 264-265.
  15. Yao-yao Yang#, Hui-qiong He#, Jia-hua Cui#, Yun-juan Nie, Ya-xian Wu, Rui Wang, Gang Wang, Jun-Nian Zheng, Richard D. Ye, Qiong Wu, Shao-shun Li, Feng Qian. Shikonin derivative DMAKO-05 inhibits Akt signal activation and melanoma proliferation. Chem. Biol. Drug Des., 2016, 87(6), 895-904. (#: Co-first author)
  16. Jinyun Dong, Zengtao Wang, Qingqing Meng, Qijing Zhang, Guang Huang, Jiahua Cui*, Shaoshun Li*. Development of 2-arylbenzo[h]quinolone analogs as selective CYP1B1 inhibitors. RSC Advances, 2018, 8(27), 15009-15020. (*: Correspondent)
  17. Jinyun Dong, Qijing Zhang, Qingqing Meng, Zengtao Wang, Shaoshun Li*, Jiahua Cui*. Chemistry and Pharmacology of Thioflavones. Mini-Rev. Med. Chem., 2018, 18(20), 1714 – 1732.
  18. Qijing Zhang, Jinyun Dong, Qing Cui, Shaoshun Li*; Jiahua Cui*. Synthesis of 4,8-dimethoxy-1-naphthol via an acetyl migration. Synth. Commun., 2017, 47(6), 536-540.

  19. Jiahua Cui*, Shaoshun Li and Jinping Jia*. 2020. "Naphthoquinone Oximes: Structure, Chemistry and Biological Activities." In Oximes: Structure, Properties and Applications, edited by Gillian Cannon. NY: Nova Science Publishers.

  20. Jiahua Cui and Shaoshun Li. 2019. " Naphthoquinone-Contained Anticancer Terrestrial Plants." In Plants that Fight Cancer, 2nd Edition, edited by Spyridon E. Kintzios and Maria G.Barberaki. Boca Raton: CRC Press.


News
Learn more